Journal of Animal Science




Association analyses of candidate single nucleotide polymorphisms on reproductive traits in swine

L. A. Rempel*, D. J. Nonneman*, T. H. Wise*, T. Erkens**, L. J. Peelman**, and G. A. Rohrer*

Abstarc :

The ability to identify young females with superior reproductionwould have a large economic impact on commercial swine production.Previous studies have discovered SNP associated with economicallyimportant traits such as litter size, growth rate, and feedintake. The objective of this study was to test for associationof candidate SNP with sow prolificacy reproductive traits ingilts of a Landrace-Duroc-Yorkshire composite population. Associationanalyses regressed additive (A), dominant (D), and imprinting(I) SNP effects on each trait with an animal model. A carnitinepalmitoyltransferase 1A SNP and a glycogen synthase 1 SNP wereassociated with age at puberty (AP; D = 10 d; P = 0. 0037 andA = 3.8 d; P = 0.0078, respectively). Four IGF2 SNP were associatedwith AP as well, having additive or dominant effects (3.2 to5.8 d; P <= 0.0052). Two mannosidase 2B2 SNP and 2 prolactin receptor(PRLR) SNP were also associated with AP. Solute carrier 22,subfamily member 5 SNP was weakly associated with AP (D = 3.9d; P < 0.10). Polymorphisms within glycogen synthase 1 andprotein kinase AMP-activated, gamma 3 noncatalytic subunit hadassociations with ovulation rate. Estrogen receptor (ESR) 1,ESR2, PPAR gamma coactivator 1, and IGFBP3 SNP were significantlyassociated with weaning-to-estrus interval. Two PRLR SNP wereassociated with total number of piglets born (A = 0.57 piglets;P = 0.0095 and D = 0.61 piglets; P = 0.0016, respectively).A SNP within PRLR was also associated with number of pigletsborn alive (D = 0.61; P = 0.0016). The PPAR gamma coactivator 1 SNPwas associated with total number of piglets born (D = 0.38 piglets;P = 0.0391) and number of piglets born alive (D = 0.53 piglets;P = 0.0032). The SNP within ESR1 (A = 0.65 piglets; P = 0.0950),ESR2 (A = –0.33 piglets; P = 0.0176), IGF2 SNP (A = –0.26piglets; P = 0.0032), and IGFBP3 SNP (D = 0.35 piglets; P =0.0683) were associated with number of piglets born dead. Aleptin SNP was associated with mummified fetuses (D = 0.09 piglets;P = 0.0978). Many of the SNP analyzed in this study are fromgenes involved in regulation of metabolism, suggesting thatthere is an important link between physiological events associatedwith reproduction and energy utilization. Furthermore, theseproduction and growth trait SNP may serve to assist in selectionof young females for superior reproductive performance.




Key Word :
pig, reproductive trait, single nucleotide polymorphism, sow longevity, swine

Volume 88, Number 1, January 2010