International Journal Of Bilogical Sciences

Roles for the Backdoor Pathway of Androgen Metabolism in Prostate Cancer Response to Castration and Drug Treatment

Michael V. Fiandalo, John Wilton and James L. Mohler 

Abstarc :

Almost all men who present with advanced prostate cancer (CaP) and many men who fail potentially curative therapy are treated with androgen deprivation therapy (ADT). ADT is not curative and CaP recurs as the lethal phenotype. The goal of this review is to describe the evolution of adrenal androgen blockade, how new androgen measurement methods have furthered understanding of androgen metabolism, and how further understanding of the backdoor pathway of androgen metabolism may lead to interventions that extend survival even more

Key Word :
Adrenal androgens, Backdoor Pathway, Prostate cancer, Dihydrotestosterone, CYP17A1.

Volume 10, Number 6, - 2014 , ISSN 1449-2288