Nature and Science

Calcitonin Gene-Related Peptide (CGRP)

Hongbao Ma

Abstarc :

 Calcitonin gene-related peptide (CGRP) is a 37 amino acid vasoactive neuropeptide that is widely
distributed in  central and  peripheral nervous systems in  mammals. CGRP was discovered in  1982 by
molecular cloning of calcitonin (CT) gene. CGRP-specific  mRNA appears to  predominate in the
hypothalamus while CT mRNA predominates in the thyroid. CGRP has an amphiphilic α-helical secondary
structure in the amino acid  sequence between 8-25. Half-life of CGRP  in mammalian plasma is about 10
min. CGRP is immunohistochemically co-localized with  substance P in cardiovascular system and it has
similar role to that of substance P. CGRP is secreted by primary afferents and causes primary hyperalgesia, and its expression increases in  dorsal horn  under sensitization conditions. CGRP  plays important  role in blood pressure system. [Nature and Science. 2004;2(3):41-47].

Key Word :
Calcitonin; calcitonin gene-related peptide; cardiovascular; substance P; neuropeptide

Volume 2, Number 3, October 2004 , ISSN 1545-0740